CORTICOTROPIC ACTIVITY OF HUMAN BLOOD*

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Abstract
The various procedures employed in the assay for corticotropin in human blood were described and analyzed. Only 2 of these procedures[long dash]the application of the assay method of Sayers and associates to untreated serum or plasma and to extracts prepared by the oxycellulose process[long dash]have yielded to the present time results which seem to be compatible with one another. The results obtained with these 2 procedures indicate that corticotropin is measurably present in the blood of patients with untreated Addison''s disease, adrenogenital syndrome, and a few miscellaneous disorders. Corticotropin is not demonstrable in the blood of patients with Cushing''s disease, nor in the blood of normal persons.