Catalytic Enantioselective Alkynylation of Prochiral sp3 C−H Bonds Adjacent to a Nitrogen Atom
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- 18 November 2004
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (26) , 4997-4999
- https://doi.org/10.1021/ol047814v
Abstract
[reaction: see text] The construction of chiral carbon centers via the first catalytic asymmetric alkynylation of prochiral CH2 groups was developed by using a copper-catalyzed double activation of sp3 and sp C-H bonds. Optically active 1-alkynylated tetrahydroisoquinolines were obtained by this method.Keywords
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