Effects of Adrenal Hormones on Capillary Permeability in Perfused Rat Tissues

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Abstract
Capillary permeability to fluid, protein and sucrose, and precapillary and postcapillary hydrodynamic resistance were measured in the perfused hindquarters of normal and adrenalectomized rats. No permeability differences between the 2 groups were observed, nor was permeability affected by adding aqueous adrenal extract to the perfusion fluid. The extract was found to contain a vasoconstrictor agent readily destroyed by oxidation in alkaline solution, and therefore presumed to be epinephrine. The reported effects of adrenal extract on capillary permeability are attributed to their vasoconstrictor action.