Utilization of Co58-labeled Vitamin B12 by Biotin-deficient Rats
- 1 November 1964
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 84 (3) , 255-258
- https://doi.org/10.1093/jn/84.3.255
Abstract
The metabolic pattern of vitamin B12 was studied in biotin-deficient rats. The livers of biotin-deficient rats had a significantly higher vitamin B12 content than those the biotin-treated animals. Absorption and excretion of orally administered Co58-vitamin B12 were not impaired in biotin-deficient rats, whereas the uptake of radioactivity by major organs was significantly higher. No difference in urine and fecal radioactivity was noted in biotin-deficient rats when Co58-vitamin B12 was administered by injection. In these animals the retention of the radiovitamin by the organs was noticeably increased.Keywords
This publication has 4 references indexed in Scilit:
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- Effect of pyridoxine deficiency on the absorption of vitamin B12Archives of Biochemistry and Biophysics, 1957
- CHOLINE IN THE NUTRITION OF CHICKSJournal of Biological Chemistry, 1941