Studies on strain sensitivity of Trichomonas vaginalis to metronidazole.

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Abstract
Ninety-four strains of T. vaginalis isolated from unselected patients in Vienna [Austria] during the period from Nov. 1974 to Nov. 1975 were subjected to sensitivity tests against metronidazole in vitro and in vivo. Nearly 90% of the isolates examined showed in vitro growth inhibition at concentrations of 0.4-1.6 .mu.g metronidazole/ml and only about 10% at concentrations < 0.4 .mu.g/ml. All isolates showed some inhibition of growth after incubation for 48 h with 3.1 .mu.g metronidazole/ml. Tests on treatment carried out experimentally infected mice revealed that all strains of T. vaginalis examined were sensitive to metronidazole (MDE: < 3 .times. 35 mg/kg peroral).