Dynamics of fluid distribution between the blood and interstitium during overhydration

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Abstract
The dynamics of fluid volume distribution between the blood and interstitium was studied in 24 anephric conscious dogs by making serial measurements of blood volume, Na-space and plasma proteins during several different states of hydration. After recovery from splenectomy and unilateral nephrectomy, the remaining kidney was removed, and i.v. infusion of lactated Ringer solution equivalent to 5%, 10%, or 20% of the body weight followed the next day. Blood volume and Na space were elevated in each infusion group for the entire 25 h postinfusion period of measurements, while total amount of circulating proteins increased in the 10% group and decreased in the 20% group, blunting the increase in blood volume in this group. During the 1st 5 h after infusion, the increase in blood volume was proportional to the increase in Na space up to a Na space of 50% above control. By 24 h postinfusion the relationship between blood volume (BV%) and Na space (SS%) as percent control was linear over the entire range of Na spaces (BV% = 68.0 + 0.32 SS%, r [correlation coefficient] = 0.99).