Delayed-onset muscular soreness and plasma CPK and LDH activities after downhill running

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Abstract
Entric and eccentric contractions. Subjective sensations of muscular soreness and plasma activities of CPK and LDH were assessed in seven subjects at 0, 24, 48, and 72 h after 45 min of running (one time on the level and a second time down a 10% incline). Following downhill running (57% of VO2max), significant delayed-onset soreness was experienced in gluteal, quadricep, anterior leg, and posterior leg muscles, and plasma CPK (but not LDH) activity was significantly increased (351% at 24 h). In contrast, following level running (78% of VO2max), no statistically significant soreness occurred in any muscle group, and plasma CPK and LDH activities were not elevated. Thus, our results generally support the hypothesis. Secondarily, we investigated whether delayed-onset soreness with downhill running is accompanied by increases in peripheral white blood cell counts suggestive of inflammation. No such association was observed. We suggest that both delayed-onset muscular soreness and plasma enzyme activities are affected by structural changes in muscle tissue resulting from eccentric contractions. ©1983The American College of Sports Medicine...