Drug Induced Interstitial Nephritis, Hepatitis and Exfoliative Dermatitis

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Abstract
Acute interstitial nephritis associated with hepatitis, exfoliative dermatitis, fever and eosinophilia is uncommon. The syndrome was described previously in association with phenindione administration, leptospirosis and heavy metal poisoning. Four cases are described, 2 of which were due to phenindione sensitivity. The other 2 patients were exposed to a number of toxins including allopurinol, frusemide, chlorothiazide and methyldopa so that the exact etiological agent is unclear. Interstitial nephritis should be considered as a cause of acute renal failure in patients with other features of drug hypersensitivity.

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