ANTAGONISM OF d -CYCLOSERINE INHIBITION OF MYCOBACTERIAL GROWTH BY d -ALANINE

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Abstract
Zygmunt, Walter A. (Mead Johnson & Co., Evansville, Ind.). Antagonism of d -cycloserine inhibition of mycobacterial growth by d -alanine. J. Bacteriol. 85: 1217–1220. 1963.—Reversal of the antimycobacterial activity of d -4-amino-3-isoxazolidinone ( d -cycloserine) by alanine in two species of mycobacteria actively growing on chemically defined media was compared. In both instances, d -alanine was the most effective reversal agent. The specificity with which the d isomer reversed the antimycobacterial activity of d -cycloserine was more pronounced than that observed with other species of bacteria. Mycobactin, a growth factor for certain mycobacteria, showed no reversal activity.