14-Esters of 7-O-(3,4-di-O-acetyl-2,6-dideoxy-.ALPHA.-L-lyxo-hexopyranosyl)adriamycinone: synthesis and antitumor activity.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (9) , 1211-1215
- https://doi.org/10.7164/antibiotics.36.1211
Abstract
A range of 14-esters of the title compound, 3''-deamino-3''-hydroxydoxorubicin 3'',4''-diacetate, was synthesized by nucleophilic substitution of the corresponding 14-bromide by the appropriate sodium carboxylase salts. Antitumor activities were determined in vivo in the murine P388 lymphocytic leukemia assay and compared with those of the 14-hydroxy and 14-acetoxy analogs.This publication has 4 references indexed in Scilit:
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