CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXIV. STUDIES ON THE NUTRITIVE VALUE OF HUMAN PLASMA FRACTIONS 1

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Abstract
Studies with young rats using plasma fractions as the sole source of protein showed human fibrin to be a high quality protein while human albumin supported no growth at all. Globulin was intermediate. Good growth could be obtained with human albumin by the addition of tryptophane and isoleucine. The amts. of tryptophane and isoleucine required for maximum growth in the young rat were found to be 0.08% of the ration for [image]([long dash])-tryptophane and 0.8% of the ration for [image]( + )-isoleucine. These amts. correspond to intakes of 94 mg. and 880 mg./kg. of body wt./day respectively. In contrast to the poor nutritional quality of albumin as found in rat growth studies, N balance in the adult dog was maintained when this protein supplied only 6% of the calories. It is estimated that no more than 1.6 mg. of tryptophane and 15 mg. of isoleucine/kg. of body wt./day are required by the adult dog.