STUDIES OF 47CA METABOLISM IN SARCOIDOSIS: EVIDENCE FOR INCREASED SENSITIVITY OF BONE TO VITAMIN D

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Abstract
Calcium metabolism was studied in two patients with sarcoidosis and hypercalcaemia before and again after treatment with prednisone. Calcium balance, miscible calcium pool (P), calcium "accretion" rate (vo+) and "bone resorption" rate (vo-) were measured. In both patients before treatment, faecal calcium was low and serum and urinary calcium were elevated, P was normal and vo+ and vo- were elevated. In both patients after treatment with prednisone, faecal calcium had increased and serum and urinary calcium, P, vo+ and vo- had decreased. The results are interpreted to mean that in sarcoidosis, the bones as well as the gastrointestinal tract are sensitive to vitamin-D.