Effects of diethyldithiocarbamate and penicillamine on the tissue distribution of 63NiCl2 in mice
- 1 May 1980
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 45 (1) , 45-52
- https://doi.org/10.1007/bf00303294
Abstract
The effects of sodium diethyldithiocarbamate and DL-penicillamine on the fate of 63Ni2+ in mice injected with 63NiCl2 were studied by whole body autoradiography and liquid scintillation counting. Sodium diethyldithiocarbamate caused a retention and redistribution of 63Ni2+ in the tissues. DL-penicillamine decreased the 63Ni2+-concentration in the tissues. The nickel-diethyldithiocarbamate complex is lipophilic, whereas the nickel-DL-penicillamine complex is hydrophilic, and these differenes in chemical properties may determine the different effects which these chelating agents have on the fate of Ni2+.Keywords
This publication has 9 references indexed in Scilit:
- The distribution and metabolism of nickel carbonyl in mice.Occupational and Environmental Medicine, 1979
- EFFICACY OF SODIUM DIETHYLDITHIOCARBAMATE (DITHIOCARB) IN ACUTE NICKEL CARBONYL POISONING1979
- AUTORADIOGRAPHIC STUDY ON THE DISTRIBUTION OF (NI-63)-CL-2 IN MICE1979
- Dithiocarbamate therapy for nickel dermatitisContact Dermatitis, 1978
- COMPARISONS OF ANTIDOTAL EFFICACY OF SODIUM DIETHYLDITHIOCARBAMATE, D-PENICILLAMINE AND TRIETHYLENETETRAMINE UPON ACUTE TOXICITY OF NICKEL CARBONYL IN RATS1977
- Effects of triethylenetetramine upon the metabolism and toxicity of 63NiCl2 in ratsToxicology and Applied Pharmacology, 1976
- COMPARISONS OF ANTIDOTAL EFFICACY OF CHELATING DRUGS UPON ACUTE TOXICITY OF NI(II) IN RATS1976
- VII. THE THERAPEUTIC EFFECTIVENESS OF ALKYL DITHIOCARBAMATES IN EXPERIMENTAL ANIMALS EXPOSED TO NICKEL CARBONYLThe Lancet Healthy Longevity, 1958
- Studies on the distribution and fate of S35-labelled benzylpenicillin in the body.1954