Advanced drug delivery reviews: enzyme prodrug therapy

This publication has 76 references indexed in Scilit:

• Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
  European Journal Of Cancer, 1995
• Initial clinical experience with oral ftorafur and oral 6R,S leucovorin in advanced colorectal carcinoma
  European Journal Of Cancer, 1993
• Synthesis and release of doxorubicin from a cephalosporin based prodrug by a β-lactamase-immunoconjugate
  Bioorganic & Medicinal Chemistry Letters, 1993
• Analysis of a conjugate between anti-carcinoembryonic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate
  Cancer Immunology, Immunotherapy, 1992
• Preparation and characterization of a .beta.-lactamase-Fab' conjugate for the site-specific activation of oncolytic agents
  Bioconjugate Chemistry, 1992
• A novel targeted delivery system utilizing a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer
  Bioorganic & Medicinal Chemistry Letters, 1991
• Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds
  European Journal of Cancer and Clinical Oncology, 1991
• Crystallization and preliminary crystallographic analysis of carboxypeptidase G2 from Pseudomonas sp. strain RS-16
  Journal of Molecular Biology, 1991
• Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide
  Cancer Immunology, Immunotherapy, 1990
• CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells
  Biochemical and Biophysical Research Communications, 1986