Antidepressant treatments, including electroconvulsive shock and the putative antidepressant sibutramine hydrochloride, do not alter [3H]-prazosin binding to rat cortical membranes

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Abstract
Treatment for 1, 3 or 10 days with sibutramine hydrochloride (3 mg/kg), desi pramine (10 mg/kg), amitriptyline (10 mg/kg) or pargyline (10 mg/kg) did not effect the number or affinity of α1-adrenoceptors as determined by [3H]-prazosin binding to rat cerebral cortical membranes. Similarly, neither single, nor repeated (five times over 10 days) electroconvulsive shocks, given under halothane anaesthesia had any effect on the parameters of [3H]-prazosin binding. These data suggest that the clinical actions of these treatments are unlikely to involve changes in α1-adrenoceptor function.