STIMULATION OF LIPOGENESIS IN BIOTIN-DEFICIENT CHICKS BY DIETARY MALONIC ACID

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Abstract
Experiments were conducted to examine possible mechanisms of dietary malonic acid stimulation of lipogenesis in biotin-deficient intact chicks. Both dietary fat and biotin deficiency reduced incorporation of acetate-14C into carcass fatty acids. Dietary malonic acid reduced acetate-14C incorporation into fatty acids by control chicks and did not restore incorporation to control levels in fat-fed and biotin-deficient chicks. The patterns of incorporation of succinate-14C and aspartate-14C were similar to the pattern of acetate-14C incorporation. Biotin deficiency did not reduce incorporation of orally administered malonate-14C into carcass fatty acids as compared with control incorporation. When unlabeled malonate was fed to biotin-deficient chicks, the percentage incorporation of malonate-14C into fatty acids was not reduced. The results suggest that dietary malonic acid is incorporated into carcass fatty acids in sufficient quantity to partially overcome inhibition of lipogenesis by biotin deficiency.

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