Effect of high dose oral Kallikrein treatment in men with idiopathic subfertility: evaluation by means of in vitro penetration test of zona free hamster ova

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Abstract
High dose oral Kallikrein treatment (600 U Padutine/day) was given to 10 infertile men with poor semen quality. After 3 mo. of this treatment no pregnancies occurred and no significant changes in routine semen characteristics were observed. Moreover, the capacity of the spermatozoa to migrate in vitro and to penetrate zona free hamster ova remained unchanged after Kallikrein ingestion. Kallikrein treatment evidently was ineffective in these men.