Effects of injection volume on the tissue dose, dose rate, and therapeutic potential intraperitoneal 32p.

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Abstract
Increasing the injection volume had no significant long-term effect on the distribution or tissue dose of i.p. 32P in New Zealand white rabbits. The range of doses and dose rates observed in the rabbit had little effect in vitro against either a human ovarian cell line or an established Chinese hamster cell line. Demonstrable kill of human ovarian cancer cells was achieved, however, for initial 32P dose rates of 11 and 22 rad/h (0.11 and 0.22 gray/h). Administered 32P activities ranging from about 75-150 mCi would be required for significant tumoricidal effects in ovarian cancer patients.