Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes: Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation
- 15 February 1991
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 41 (4) , 553-560
- https://doi.org/10.1016/0006-2952(91)90627-h
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- Oxidative activation of the thiophene ring by hepatic enzymesBiochemical Pharmacology, 1990
- Hydroxylation of the thiophene ring by hepatic monooxygenasesBiochemical Pharmacology, 1990
- The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal LociDNA, 1989
- Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiencyBiochemistry, 1987
- The in Vitro and in Vivo Metabolism of Morantel in Cattle and Toxicology SpeciesDrug Metabolism Reviews, 1987
- Metabolic hydroxylation of the thiophene ring: Isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and ratBiochemical Pharmacology, 1984
- Metabolism of tenoxicam in ratsXenobiotica, 1984
- Cytochrome P-450 Monooxygenase Activities in Human and Rat Liver MicrosomesEuropean Journal of Biochemistry, 1981
- Synthese d'un diuretique marque au carbone 14: Acide dichloro‐2,3 [thenoyl‐2 (14C = 0)]‐4 phenoxy acetique (D.C.I. acide tiénilique)Journal of Labelled Compounds and Radiopharmaceuticals, 1976
- The Metabolism of Thiophen in the Rabbit and the RatXenobiotica, 1971