ENHANCED EFFECT OF GASTRIN ON RAT STOMACH CARCINOGENESIS INDUCED BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (5) , 1781-1787
Abstract
The effects of gastrin on the incidence of gastric tumors in rats induced by N-methyl-N''-nitro-N-nitrosoguanidine were studied. Inbred Basel-Wistar rats received N-methyl-N''-nitro-N-nitrosoguanidine in drinking water (50 .mu.g/ml for 32 wk) to produce gastric carcinoids. A treatment with s.c. injection of pentagastrin (300 .mu.g/kg, once daily for 4 wk) was started at the beginning of N-methyl-N''-nitro-N-nitrosoguanidine treatment simultaneously on the 4th, 8th, 16th and 32nd wk after start of N-methyl-N''-nitro-N-nitrosoguanidine treatment, respectively. At autopsy, from the 55th-60th wk after start of the experiment, only in the 8th-wk group of gastrin-treated rats was the incidence of gastric carcinoid significantly higher than in the gastrin-untreated group of rats receiving N-methyl-N''-nitro-N-nitrosoguanidine alone. The incidence of adenocarcinoma in the glandular stomach also was high only in the 4th-wk group of gastrin-treated rats. These effects could not be seen in other gastrin-treated or untreated groups of rats. Gastrin treatment in the eary stage of rat stomach carcinogenesis by N-methyl-N''-nitro-N-nitrosoguanidine is apparently effective in increasing the development of gastric tumors.