Bonding of alkali- and heat-treated tantalum implants to bone

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Abstract
Alkali‐ and heat‐treated tantalum (Ta) has been shown to bond to bone. The purpose of this study was to investigate the effects of chemical treatments on the bone‐bonding ability of tantalum implants in rabbit tibiae. Miyazaki et al. reported in vitro that alkali‐ and heat‐treated tantalum had an apatite forming ability in an acellular simulated body fluid (SBF). In this study, smooth‐surfaced rectangular plates (15 × 10 × 2 mm) of pure tantalum and treated tantalum were prepared. The plates were implanted transcortically into the proximal metaphyses of bilateral rabbit tibiae, alkali‐ and heat‐treated plates for one limb and untreated plates for the contralateral limb, which served as a paired control. Bone bonding at the bone/implant interface was evaluated by tensile testing and undecalcified histological examination, at 8 and 16 weeks after implantation. The treated implants showed weak bonding to bone at 8 weeks, and exhibited significantly higher tensile failure loads compared with untreated tantalum implants at 16 weeks. The untreated implants showed almost no bonding, even at 16 weeks. Histological examination by Giemsa surface staining, contact microradiography (CMR), and scanning electron microscopy (SEM) revealed that treated tantalum implants bonded directly to bone tissue. In contrast, the untreated tantalum implants had a intervening fibrous tissue layer between the bone and the plate and did not bond to bone at 8 and 16 weeks. It is clear from these results that alkali and heat treatment induce the bone‐bonding ability of tantalum. This new bioactive tantalum should be an effective material for weight‐bearing and bone‐bonding orthopedic devices. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 53: 28–35, 2000

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