Properties of Hepatitis B e Antigen Synthesized by Rat Cells Transfected with Circular Viral DNA
- 1 August 1984
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 65 (8) , 1373-1383
- https://doi.org/10.1099/0022-1317-65-8-1373
Abstract
Transfection of Buffalo rat liver cells with closed circular hepatitis B virus DNA resulted in the synthesis of both hepatitis B e and surface antigens. A 14,000 MW peptide bearing hepatitis B e antigenic determinants was isolated from cell culture fluids. Native hepatitis B e antigen was present in multimeric forms in the cell culture fluids and was associated with protein phosphokinase activity. The multimeric forms of hepatitis B e antigen may serve both structural and enzymic functions for the hepatitis B virion with its small genome.This publication has 24 references indexed in Scilit:
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