IMMUNOLOGICAL REACTIVITY OF GLYCOPROTEIN ANTIGENS FROM HUMAN-LUNG CANCERS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 27  (6) , 641-652
Abstract
Glycoprotein antigens were extracted with perchloric acid (PCA) from 14 individual lung anaplastic cancers and 4 lung adenocarcinomas and their antigenic activity was compared with carcinoembryonic antigen (CEA) isolated from liver metastases of colon cancer. The studies were performed by double immunodiffusion, immunoelectrophoresis and radioimmunoassay, using the specific immune sera against PCA-extracted glycoproteins of lung anaplastic cancer (anti-80 PCA-CaLu) and also anti-CEA. anti-AFP [.alpha.-fetoprotein] and anti-.alpha.1-acid glycoprotein sera. The existence of at least 3 groups of antigens in lung cancers was demonstrated, i.e., CEA-like antigen, group antigen characteristic for most of the lung anaplastic cancers and lung adenocarcinomas non-related to CEA and antigen(s) detectable only in some anaplastic cancers. Antigen of .alpha.1-acid glycoprotein reactivity was detected in all lung cancers studied.