Modifications des fractions phosphatidiques chez des patients présentant une hypercholestérolemia d’étio-pathogénie variée

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Abstract
The phospholipidic fractionation was studied on 30 hypercholesterolemie patients with various etio-pathogenesis (Buerger''s disease, nephrotic syndrome, essential hypercholesterolemia, arteriosclerosis myocardial infarction and diabetes mellitus. The phospholipidic fraction (thin-layer chromatography) and the cholesterol/phospholipid (C/P)ratio were determined. The results show an increase of the C/P value in 24 cases out of 30 cases (which corresponds to 80%). In cases where the C/P values remain within the standard limits, substantial modifications of the various phospholipidic fractions were not seen. On the other hand, in patients with an abnormally high value of C/P, there was, in 62.5% of cases, a decrease of lecithins, and in 66.6% an increase of lysoleci-thins. The same patients failed to display similarly significant variations of sphingomyelins and of cephalins. Whereas the decrease of lecithins is discussed on the basis of physical and therapeutic properties and of experimental observations adduced in the literature for this phosphatide, it is not possible at present to give an interpretation of the increase of lysolecithins.