Acute Reduction of Plasma Nonesterified Fatty Acid by Growth Hormone in Hypophysectomized and Houssay Rats1

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Abstract
Intraperitoneal administration of 1 or 3 mg of bovine growth hormone (GH, NIH-916) to hypophysectomized Sprague-Dawley rats evoked a diminution of plasma nonesterified fatty acids (NEFA) at 30 and 60 min. These effects were clearly distinct from the commonly observed elevation at 2–6 hr. Hypoglycemia and hypoaminoacidemia were associated temporally with the decline in plasma NEFA, Epididymal fat pads at 6 hr showed increased relative water content, as indirect evidence of intense lipid mobilization. Subtotal (95 %) pancreatectomy 3–5 days prior to removal of the hypophysis failed to prevent the 1 hr reduction of plasma NEFA in response to GH. A dose of ACTH 3 times greater than that calculated as a maximum contaminant in the larger of the GH doses used failed to elicit the 1 hr NEFA decline. The acute diminution of plasma NEFA strongly suggests, from temporal relations alone, that the adipokinetic response is not a primary effect of GH. (Endocrinology76: 665, 1965)