Preventive Action of Tranylcypromine on Alloxan Diabetes in Rats

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Abstract
The intraperitoneal injection of tranylcypromine (25 mg/kg) 20 min before the intravenous administration of alloxan prevents the onset of diabetes in the rat. The same protective effect is observed when the monoamine-oxidase inhibitor is injected intravenously (10 mg/kg) 15 sec before alloxan. When these 2 drugs are mixed in vitro and injected intravenously, the protection disappears. This protective action against diabetes indicates that tranylcypromine protects important enzymatic centers against the action of alloxan at the pancreatic level.