Cholinesterase studies of neurologic mutants in mice

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Abstract
Three neurological mutant strains of mice names tremulous, waddler, and quivering were studied for their serum choiinesterase activities. The enzymic levels were lower in both male and female tremulous mice compared with their normal sibs. This was also true with quivering females, but no difference was found between quivering males and their normal brothers. On the other hand, waddler males showed a higher enzymic level compared with their normal brothers, but no difference was found between waddler females and their normal sisters. In addition to the now well-established sex differences, some significant strain differences were observed. From the above results, it was concluded that the serum choiinesterase levels are altered in the 3 neurologic conditions investigated, but that the final expression of these alterations in enzymic levels is dependent upon the interaction of the original enzymic changes and the genetic constitution of the mice in which these changes occur. Various tests showed that the serum choiinesterase in mice is predominantly pseudocholinesterase and true choiinesterase activity is negligible.

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