Effect of Antigonadotrophic Serum on Testes of A-Strain Mice Treated with Estrogen

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Abstract
Male A-strain mice treated simultaneously with estrogen and normal rabbit serum developed extensive interstitial cell hypertrophy and hyperplasia. Animals receiving an antigonadotropic serum prepd. by injecting a crude sheep pituitary extract into rabbits failed to show the same intensive interstitial cell changes. The consequent suppression of the interstitial cell hypertrophy and hyperplasia, which normally occurs in this strain of mice when treated with estrogen, provides further evidence that the pituitary gland participates in growth and development of interstitial cell tumors. The possibility that the antiserum exerts an aspecific toxic effect is considered.