Tumor Concentration of Platinum in Patients with Head and Neck Cancer
- 1 June 1983
- journal article
- research article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 91 (3) , 271-275
- https://doi.org/10.1177/019459988309100312
Abstract
Simultaneous concentrations of total plasma platinum, filterable platinum, intact cisplatin, and total tumor platinum were measured for 24 hours after an intravenous bolus of cisplatin in five patients. Tumor concentrations of drug were greater than could be explained on the basis of circulating plasma platinum at the time of biopsy. Intratumor platinum concentrations derived from this study provide guidance for selection of the appropriate drug concentrations for in vitro chemosen-sitivity testing of head and neck cancer in humans.Keywords
Funding Information
- National Institutes of Health (P01‐Ca 30195)
- National Cancer Institute (CA‐09242, CA‐24384)
This publication has 6 references indexed in Scilit:
- High-performance liquid chromatography of inorganic platinum(II) complexes using solvent-generated anion exchangers : II. The effect of electrolytes on solute retentionJournal of Chromatography A, 1981
- Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapyThe American Journal of Medicine, 1981
- Analysis of Total Platinum in Tissue Samples by Flameless Atomic Absorption Spectrophotometry. Elimination of the Need for Sample DigestionAnalytical Letters, 1981
- In vitro stem cell assay in head and neck squamous carcinomaThe American Journal of Surgery, 1980
- Role of chemotherapy in head and neck cancer: Systemic use of single agents and combinations in advanced diseaseHead & Neck Surgery, 1980
- Primary Bioassay of Human Tumor Stem CellsScience, 1977