EFFECT OF ENDRIN ON VENOUS RETURN AND CATECHOLAMINE RELEASE IN THE DOG

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Abstract
Previous reports have shown that dogs treated with the insecticide endrin develop marked changes in blood pressure and heart rate accompanied by convulsions terminating in death. The present study was designed to determine the relationship between venous return (cardiac output), total peripheral vascular resistance, and hypertension seen in succinylcholine-treated dogs after a lethal dose of endrin. Experiments were performed on "intact" (viscera intact) and eviscerated dogs under conditions of total body perfusion. Results indicate that the rise in systemic arterial blood pressure depends primarily on increased cardiac output due to an elevated venous return. Total peripheral resistance does not change significantly in either group of animals. The abdominal viscera were the primary source of the increase in venous return after endrin. Adrenal glands were partially depleted of adrenaline, and increased levels of adrenaline and noradrenaline found in blood plasma may explain the marked alterations in systemic hemodynamics.