Microbial transformation of cannabinoids. I. Metabolism of ( - )-Δ9-6a,10a-trans-Tetrahydrocannabinol by Chaetomium globosum
- 1 January 1978
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 31 (8) , 1799-1807
- https://doi.org/10.1071/ch9781799
Abstract
Chaetomium globosum isolated from Cannabis sativa plant material converts (-)-Δ9-6a,10a-frans-tetrahydrocannabinol (Δ9-THC) (1a) into a number of metabolic products, which include the 3'-hydroxy, 11-hydroxy and 3',11-dihydroxy derivatives (1c), (1b) and (1d) respectively. The structure of the 3'-hydroxy-Δ9-THC (1c) has been confirmed by synthesis, whilst the structure of the 3',11-dihydroxy-Δ9-THC (1d) follows from mass spectroscopic comparison with the 3'-hydroxy and 11-hydroxy derivatives.Keywords
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