Effect of nitrophenols and halogenophenols on the enzymic activity of rat-liver mitochondria

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Abstract
Of a series of nitro- and halogeno-phenols, it is shown that qualitatively there is a resemblance to 2,4-dinitrophenol with respect to the action towards rat-liver mitochondria. Quantitatively, it is further demonstrated that these compounds can be divided into 2 groups based upon the characteristics of their behavior towards oxidative phosphorylation, oxidation of glutamic acid and release or activation of latent adenosine triphosphatase. There is a correlation between activity of these compounds in vitro and their dissociation constants which is modified by nitro groups ortho to the hydroxyl group. The hydrolysis of some of the corresponding nitro- and halogeno-phenyl phosphates is described.