Sickle cell disease: old discoveries, new concepts, and future promise
Top Cited Papers
Open Access
- 2 April 2007
- journal article
- review article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 117 (4) , 850-858
- https://doi.org/10.1172/jci30920
Abstract
The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.Keywords
This publication has 152 references indexed in Scilit:
- A two-year pilot trial of hydroxyurea in very young children with sickle-cell anemiaThe Journal of Pediatrics, 2001
- Stroke in a cohort of patients with homozygous sickle cell diseaseThe Journal of Pediatrics, 1992
- Hematologic Responses of Patients with Sickle Cell Disease to Treatment with HydroxyureaNew England Journal of Medicine, 1990
- Prophylactic Red-Cell Transfusions in Pregnant Patients with Sickle Cell DiseaseNew England Journal of Medicine, 1988
- Prophylaxis with Oral Penicillin in Children with Sickle Cell AnemiaNew England Journal of Medicine, 1986
- Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by HydroxyureaNew England Journal of Medicine, 1984
- 5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+ThalassemiaNew England Journal of Medicine, 1982
- Improved Detection of the Sickle Mutation by DNA AnalysisNew England Journal of Medicine, 1982
- The Interaction of Alpha-Thalassemia and Homozygous Sickle-Cell DiseaseNew England Journal of Medicine, 1982
- The Inheritance of Sickle Cell AnemiaScience, 1949