Mechanism of Action of Nikkomycin and the Peptide Transport System of Candida albicans
- 1 April 1985
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 131 (4) , 775-780
- https://doi.org/10.1099/00221287-131-4-775
Abstract
Nikkomycin was a potent growth inhibitor of C. albicans through competitive inhibition of chitin synthase [Ki = 0.16 .mu.M (0.1 ml-1)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective antagonists while transported oligopeptides were not. A mutant of C. albicans resistant to the effects of nikkomycin through a transport defect was unable to transport dipeptides, while oligopeptide uptake was apparently unaffected. At least 2 peptide permeases are operational in this organism.This publication has 8 references indexed in Scilit:
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