Hyperphagia and Increased Growth in Rats After Intraventricular Injection of 5,7-Dihydroxytryptamine
- 23 April 1976
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 192 (4237) , 385-387
- https://doi.org/10.1126/science.1257774
Abstract
Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 days after the injections revealed 60 to 86 percent depletions of telencephalic 5-hydroxytryptamine, with catecholamine levels unchanged. Hyperphagia did not develop despite comparable losses of 5-hydroxytryptamine when the pretreatment was withheld, perhaps because substantial depletions of norepinephrine occurred as well.Keywords
This publication has 31 references indexed in Scilit:
- Hyperphagia and Obesity Following Serotonin Depletion by Intraventricularp-ChlorophenylalanineScience, 1976
- Delayed hyperphagia and increased body length after hypothalamic knife cuts in weanling rats.Journal of Comparative and Physiological Psychology, 1975
- Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.Journal of Comparative and Physiological Psychology, 1974
- Overeating and Obesity from Damage to a Noradrenergic System in the BrainScience, 1973
- Evidence for ascending noradrenergic mediation of hypothalamic hyperphagiaPharmacology Biochemistry and Behavior, 1973
- Modification du me´tabolisme de la se´rotonine (5-HT) ce´re´brale induite chez le rat par administration de 6-hydroxydopamineBrain Research, 1973
- Conjoint native and orthophthaldialdehyde-condensate assays for the fluorimetric determination of 5-hydroxyindoles in brainNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1973
- Increases in Plasma Growth Hormone Concentration and Naso-Anal Length in Rats Following Isolation of the Medial Basal HypothalamusNeuroendocrinology, 1973
- ELECTROPHYSIOLOGICAL CORRELATES AND NEURAL SUBSTRATES OF ALIMENTARY BEHAVIOR IN THE CAT*Annals of the New York Academy of Sciences, 1969
- An Improved Method for Fluorimetric Determination of Small Amounts of Adrenaline and Noradrenaline in Plasma and TissuesActa Physiologica Scandinavica, 1963