Approaches to vasodilating/.beta.-adrenergic blocking agents: examples of the dihydrolutidine type
- 1 May 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 24 (5) , 628-631
- https://doi.org/10.1021/jm00137a028
Abstract
The aminohydroxypropoxy moiety was incorporated into the dihydrolutidine class of vasodilators. In the spontaneously hypertensive rat, one of these, (S)-4-[2-methyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl-3,5-dicarboethoxy-1,4-dihydrolutidine (4c), exhibited antihypertensive activity on the order of the standard 4-[2-(trifluoromethyl)phenyl]-3,5-dicarboethoxy-1,4-dihydrolutidine (2a). This antihypertensive activity could not be explained in terms of a vasodilating effect, as determined in the dog. In this latter model, 2a decreased mean arterial and hindlimb perfusion pressures.This publication has 7 references indexed in Scilit:
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