Effect of the Flavonoids Biochanin A and Silymarin on the P-Glycoprotein-Mediated Transport of Digoxin and Vinblastine in Human Intestinal Caco-2 Cells
- 1 January 2003
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 20 (8) , 1184-1191
- https://doi.org/10.1023/a:1025044913766
Abstract
Purpose.The purpose of this study was to investigate the effects of flavonoids biochanin A and silymarin on intestinal absorption of P-gp substrates by determining their effects on P-gp-mediated...Keywords
This publication has 35 references indexed in Scilit:
- P-Glycoprotein–Mediated Transport of Berberine across Caco-2 Cell MonolayersJournal of Pharmaceutical Sciences, 2002
- Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane‐induced colon carcinogenesis in male F344 ratsInternational Journal of Cancer, 2002
- Effect of Milk Thistle on the Pharmacokinetics of Indinavir in Healthy VolunteersPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2002
- The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and CancerPharmacological Reviews, 2000
- The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemiaAtherosclerosis, 2000
- BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTERAnnual Review of Pharmacology and Toxicology, 1999
- Pharmacological insights from P-glycoprotein knockout mice.1998
- Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.Journal of Clinical Investigation, 1997
- P-glycoprotein—A mediator of multidrug resistance in tumour cellsEuropean Journal Of Cancer, 1996
- Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapyMolecular Carcinogenesis, 1995