Meal Stimulated Gastrin and Pancreatic Polypeptide Levels Before and After Partial Gastric Transection for Morbid Obesity

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Abstract
The basal and meal stimulated plasma gastrin and pancreatic polypeptide levels in 6 morbidly obese patients were determined before and after partial gastric transection (gastroplasty), an operation which results in the distention of the stomach with a small volume of food. The partial gastric transection involved the creation of a proximal gastric pouch of .apprx. 100 ml, with a 1.2 cm diameter lumen between the proximal and distal gastric pouch. Basal gastrin and pancreatic polypeptide were not altered by the operation. The magnitude of the pancreatic polypeptide response to the meal was significantly depressed, although the time course was not changed. Inhibition of pancreatic secretion is thought to be a physiological function of pancreatic polypeptide, hence its decreased release warrants further investigation of the effect of partial gastric transection on pancreatic function.