Effects of 2,4-Dinitrophenol on Respiration in the Dog

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Abstract
The intravenous administration of 2,4-dinitrophenol (DNP) to unanesthetized or anesthetized dogs produced an increase in arterial pH and decrease in arterial Pco2 which preceded any significant rise in body temperature. Thus the hyperventilation associated with DNP-administration appears not to be solely the result of increased production of CO2. Although DNP in small amounts stimulated respiration via the carotid body, larger doses still produced increased ventilation and pH and decreased Pco2 after denervation of the carotid bodies and bilateral vagotomy, thus demonstrating a stimulatory effect of DNP at some more central site as well. DNP increased the sensitivity of the respiratory center (or its afferent connections) to Pco2 and/or concentration of hydrogen ion. The similarities of respiratory effects of DNP and salicylate are discussed. An unexplained increase in ‘buffer base’ of the blood occurred in association with the respiratory alkalosis induced by DNP.