Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.

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Abstract
Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2R.alpha. chain and the 70-kDa IL-2R.beta. chain. The low-affinity, IL-2R.alpha. chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2R.beta. receptor. We report here identification of the genomic locus for IL-2R.beta.. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5''-most end of the genomic locus and contains promoter sequences. The promoter contains on TATA box-like elements but does contain the d(GT)n class of middle repetitive elements, which may play an interesting regulatory role. The IL-2R.beta. gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.