An experimental investigation of the “ring hypothesis” of arsenical toxicity
- 1 January 1947
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 41 (1) , 56-62
- https://doi.org/10.1042/bj0410056
Abstract
A series of [alpha][omega] -dithiols from ethane to dodecane and butane-, hexane-, heptane-, 2-ethylhexanethiol, were synthesized and tested for antidotal efficiency against the pyruvate oxidase system of pigeon brain inhibited by lewisite.. The dithiols were all very effective, the monothiols ineffective. These results support the hypothesis that arsenical toxicity depends on the formation of cyclic thio-arsinites; the [alpha][omega]-dithiols form cyclic thioarsinites of greater stability.Keywords
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