The Kinetics of DNA Uptake by Haemophilus influenzae

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Abstract
SUMMARY: The rates of formation of transformed cells in mixtures of transforming DNA and transformable Haemophilus influenzae bacteria have been measured. The data were interpreted as follows. About 4–5 sec. are required for the penetration of a DNA particle of 8–9 x 106 mean molecular weight. The average number of penetration sites per bacterium is probably two. There is no reversible attachment of DNA to these sites. Crude calculations show that about one out of every two encounters between a bacterium and a DNA molecule results in the penetration of the latter into the cell.

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