Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-Mediated Vinylic Substitution

5 April 2000

journal article
research article
Published by American Chemical Society (ACS) in Organic Letters

Vol. 2 (9) , 1333-1336
https://doi.org/10.1021/ol005800t

Abstract

A new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides. Modified reaction conditions have been developed to synthesize the O-methyloxime enamide side chains related to the natural products lobatamides A−F, oximidine I and II, and CJ-12 950.

Keywords

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