On the cooperative binding of large ligands to a one‐dimensional homogeneous lattice: The generalized three‐state lattice model

Abstract
We present the general secular equation for three-state lattice models for the cooperative binding of large ligands to a one-dimensional lattice. In addition, a closed-form expression for the isotherm is also obtained, that can be used with all values of the cooperativity parameter ω(0 < ω < ∞) thus eliminating the need for multiple equations.