EFFECTS OF CHRONIC RENAL DISEASE ON THYROID HORMONE METABOLISM

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Abstract
Serum concentrations of total and free thyroxine T4 and triiodothyronine, and urine losses of unconjugated thyroid hormones were measured in normal subjects and in patients with renal disease. Serum total hormone values in the hypothyroid range were common in the renal group and correlated inversely with the degree of renal impairment but not with renal loss of hormone which in the case of T4 exceeded the average normal daily loss 10-fold. The euthyroid state of patients with renal disease was best reflected by serum free T4 concentration which in every case was within the normal range. Poor correlation was apparent between the respective urine concentrations of albumin and T4, and the reasons for this are discussed.

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