DEMONSTRATION OF HEMATOPOIETIC STEM-CELLS IN PERIPHERAL-BLOOD OF BABOONS BY CROSS CIRCULATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 50  (3) , 537-542
Abstract
Baboons [Papio papio] were given 1200 R total body irradiation from 2 opposing 60Co sources. Three animals were given supportive therapy only and died, as expected, within 8 days of irradiation with profound marrow hypoplasia. Five baboons were cross-circulated with unirradiated partners and died within 14 days with evidence suggestive of graft-vs.-host disease. Their marrows were repopulated with hemopoietic precursor cells, and 3 of the 5 had rises in peripheral white blood cell counts to more than 1500/cu mm before death. These results are compatible with the presence of hemopoietic stem cells in the peripheral blood of a nonhuman primate, the baboon.