Suppressive effect of graft versus host reactions on the immune response to heterologous red cells.
- 1 April 1971
- journal article
- Vol. 20 (4) , 597-609
Abstract
Graft versus host (GVH) reactions induced by the inoculation of parental spleen cells into adult untreated F1 recipients caused a marked suppression of the cellular and humoral immune response to sheep red cells (SRBC) and Escherichia coli lipopolysaccharide, provided the GVH reaction was induced 7 days before immunization with SRBC. Adoptive transfer of parental or F1 spleen cells mixed with SRBC into irradiated F1 recipients, which had been subjected to a GVH reaction for 7 days, resulted in marked suppression of cellular antibody synthesis to both antigens.This publication has 14 references indexed in Scilit:
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