The specificity of skin-sensitizing antibodies in the guinea-pig.

  • 1 May 1970
    • journal article
    • Vol. 6  (5) , 741-51
Abstract
In this paper the specificity of the skin-reactive guinea-pig immunoglobulin in the homologous PCA test has been reconsidered. Extensive purification of this immunoglobulin by chromatographic methods results in the isolation of a small fraction of medium speed immunoglobulins that contains all skin reactivity. No correlation could be found with the 7S immunoglobulins IgGγ1 and Igγ1A, suggesting a separate class of biologically active immunoglobulins. The PCA active antibody belongs to either an IgG subclass or is a heat stable homocytotropic antibody.