Lysinomicin, a new aminoglycoside antibiotic. II. Structure and stereochemistry.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (10) , 1130-1143
- https://doi.org/10.7164/antibiotics.37.1130
Abstract
The structure of lysinomicin, a new aminocyclitol antibiotic [antibacteria], was established as 3-epi-2''-N-(L-.beta.-lysyl)-4'',5''-didehydro-6''-de-C-methylfortimicin B (1) on the basis of spectral evidence and chemical degradation of the antibiotic. In the course of degradation of 1 3 addititional compounds with interesting biological properties were obtained: 3-epi-2''-n-(L-.beta.-lysyl)-6''-de-C-methylfortimicin B; 3-epi-4'',5''-didehydro-6''-de-C-methylfortimicin B; and 3-epi-6''-de-C-methylfortimicin B.This publication has 5 references indexed in Scilit:
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- Substances derived from 4-de-N-methylfortimicin B.The Journal of Antibiotics, 1981
- 2′-N-acylfortimicins and 2′-N-alkylfortimicins via the isofortimicin rearrangement1Carbohydrate Research, 1980
- Synthese de derives de la purpurosamine C,composant de la gentamicine C1aTetrahedron, 1977
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