Discovering Nature's Diverse Pathways to Vitamin B12: A 35-Year Odyssey
- 28 March 2003
- journal article
- review article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (7) , 2529-2539
- https://doi.org/10.1021/jo020728t
Abstract
The chronology of the discoveries along the pathway of vitamin B12 biosynthesis is reviewed from a personal perspective, including discussion of the most recent finding that two pathways to B12 existone aerobic and one anaerobicwhich differ mainly in the ring contraction mechanisms that convert porphyrin to corrin.Keywords
This publication has 58 references indexed in Scilit:
- The Escherichia coli cysG gene encodes the multifunctional protein, siroheme synthaseFEBS Letters, 1993
- Biosynthesis of vitamin B12FEBS Letters, 1993
- Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis Identification of the 11‐methyl and 20‐methyl transferases of corrin biosynthesisFEBS Letters, 1992
- Enzymatic synthesis of dihydrosirohydrochlorin (precorrin‐2) and of a novel pyrrocorphin by uroporphyrinogen III methylaseFEBS Letters, 1990
- Studies on the biosynthesis of corrinoids and porphyrinoids. I. The labeling of oxygen of vitamin B12.CHEMICAL & PHARMACEUTICAL BULLETIN, 1989
- Evidence for a dipyrromethane cofactor at the catalytic site of E. coli porphobilinogen deaminaseFEBS Letters, 1987
- Biosynthesis of vitamin B12: order of the later C-methylation stepsJournal of the Chemical Society, Chemical Communications, 1985
- Biosynthesis of vitamin B12: pulse labelling experiments to locate the fourth methylation siteJournal of the Chemical Society, Chemical Communications, 1982
- Biosynthesis of corrinoids. Uroporphyrinogen III as a precursor of vitamin B12Journal of the American Chemical Society, 1972
- Biosynthesis of corrinoids. Origin of the methyl groups in vitamin B12Journal of the American Chemical Society, 1972